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An acute myopathy has been observed with the use of high doses of corticosteroids, most frequently occurring in patients with disorders of neuromuscular transmission (eg, myasthenia gravis), or in patients receiving concomitant remedy with neuromuscular blocking medicine (eg, pancuronium).
The Beers knowledgeable panel notes that oral and parenteral corticosteroids may be required for situations resembling exacerbation of chronic obstructive pulmonary illness (COPD) but must be prescribed within the lowest efficient dose and for the shortest potential length.
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